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The aircraft's left engine fell off as the plane rolled toward takeoff, according to safety investigators. At least 12 people died after the plane plunged to the ground.
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Kentucky Gov. Andy Beshear (D) said news of the fatalities was "heartbreaking" and that the death toll could rise.
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The UPS cargo plane crash on Tuesday at the company's global aviation hub in Kentucky, which killed at least nine, will temporarily disrupt the supply chain and result in some shipping delays.
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