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The actor, who also starred in HBO's Euphoria, battled the most common form of motor neurone disease.
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His breakout role came in 2006 as the handsome Dr. Mark Sloan, nicknamed McSteamy, the head of plastic surgery at a Seattle hospital. He died 10 months after announcing his A.L.S. diagnosis.
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The news arrives 10 months after the Euphoria actor revealed he had been diagnosed with amyotrophic lateral sclerosis
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