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Three people with possible symptoms of the disease were evacuated on Wednesday morning from the MV Hondius before it headed to the Canary Islands.
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They do not have symptoms and health officials say the risk to the general public remains very low.
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More than 140 people remain on the Hondius, which will take about three days to reach the Spanish archipelago for screening. A local official has criticized the plan.
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The cruise ship at the the center of a deadly hantavirus outbreak faced a new challenge Wednesday as a local leader opposed allowing it to dock in Spain, while authorities confirmed the Andes strain, which can be spread among people, was identified in passengers
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While passengers onboard the MV Hondius say the situation is calm, they face days at sea as officials warn the disease may have spread.
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