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As Israeli Prime Minister Benjamin Netanyahu vowed to fight "as long as it takes," Iran fired missiles at Israel, and Israeli warplanes attacked air defenses around Tehran.
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The Iranian and Israeli strikes mark the most sustained, direct attacks ever between the two rivals. Three people were killed in Israel and at least 78 in Iran, officials said.
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 Iran launched retaliatory missile strikes on Israel into Saturday morning, killing at least three people and wounding others, after a series of blistering Israeli attacks on the heart of Iran's nuclear program and its armed forces.
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Explosions could be heard in Tel Aviv on Friday night local time, as sirens rang out across Israel amid what the Israeli military said was an Iranian missile attack.
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Israeli military assaults on the Gaza Strip's hospitals have ramped up in recent weeks to the highest level so far this year, bringing a health system already weakened by 19 months of war to a breaking point.
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Israeli strikes leave Iran's wounded government facing a number of questions, including whether it should give up on negotiations and rush its nuclear program.
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Information on the latest incident is scarce as the internet has been down in Gaza for more than two days.
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 The federal government is urging Canadians to "avoid all travel" to Israel as the country exchanges missile and air strikes with Iran.
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Israeli authorities have indicated that this could be the beginning of a prolonged campaign against Iran.
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Israel's defense minister warned Iran that "Tehran will burn" if it keeps firing missiles at Israeli civilians.
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Iran fired a wave of missiles at Israel tonight, but most were intercepted by Israeli air defenses. It followed Israel's strikes on Iran's military leadership and nuclear facilities. NBC News' Matt Bradley reports.
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Iran fired missiles at Israel late Friday after waves of Israeli strikes killed senior Iranian commanders and nuclear scientists in Tehran.
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