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The Iranian and Israeli strikes mark the most sustained, direct attacks ever between the two rivals. Three people were killed in Israel and at least 78 in Iran, officials said.
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Israel launches new strikes in response to Iranian counterattacks
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Explosions could be heard in Tel Aviv on Friday night local time, as sirens rang out across Israel amid what the Israeli military said was an Iranian missile attack.
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"Iran must make a deal, before there is nothing left, and save what was once known as the Iranian Empire," President Donald Trump said.
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Among the military figures killed is Mohammad Bagheri, the highest-ranking officer in Iran.
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Interviews with half a dozen senior Iranian officials show that they were not expecting Israel to strike before another round of talks.
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