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The conflict in the Middle East has rattled financial markets and global energy prices have soared.
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Retaliatory Iranian strikes on Gulf states have tarnished their image as safe and prosperous, writes the BBC's Barbara Plett-Usher.
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The S&P 500 recovered ground in the afternoon but still ended the day lower, as investors sought cover from the unpredictable effects that the fighting could have on the world economy.
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By reaching 40 points with victory at Leeds on Tuesday, Sunderland have pretty much ensured Premier League survival by early March.
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The Isfahan facility, suspected of storing a cache of enriched uranium, was smashed during the 12-day campaign last June.
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